Femme et flore intestinale
Femme et flore intestinale
Femme et flore intestinale
Femme et flore intestinale

C. difficile

Clostridium difficile is a bacterium that normally resides without causing any problem in the gut of approximately 5% of the population1. Following antibiotic treatment, the bacterial colonization in the intestine decreases which promotes the proliferation of C. difficile and thereby the infection by the bacteria. Well entrenched the bacteria produce toxins that can damage the gut and cause diarrhea2. Clostridium difficile-associated diarrhea (CDAD) is the leading cause of nosocomial diarrhea3.


Common symptoms of an infection are

  • Diarrhea
  • Abdominal cramps
  • Fever
Clostridium difficile

Most people with the disease recover with antibiotic treatment, although researchers estimate that more than 20% of patients with C. difficile infection fail initial treatment4. Moreover, some more vulnerable patients may have serious complications such as severe bowel inflammation or severe dehydration2.

It is also possible to find blood, mucus or pus in the stools.

People taking antibiotics are 7 to 10 times more likely to have the infection5. People in hospitals or nursing homes are also more at risk6.

The administration of Probaclac probiotics as a preventative measure to prevent the spread of C. difficile infections has been effective7.

Probaclac Vaginal
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61%
reduction rate of C. Difficile infection cases

Montreal-based Santa Cabrini Hospital administered Probaclac Adult probiotics to all patients who received antibiotic treatment to control the spread of the infection. The CDAD decreased in patients at the hospital.

Conducted over a period of 8 months with 5000 people, the double-blind study was completely independent of Laboratoires Nicar.

The administration of Probaclac probiotics as a preventative measure to avoid the spread of C. difficile infections has been effective7.


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Antibiotic associated diarrhea - AAD

A supplement of Saccharomyces boulardii should always accompany antibiotic therapy.


Broad-spectrum antibiotics work against a large number of bacteria to fight infections.

They are an effective weapon to handle with caution as they attack bacteria without distinguishing between pathogenic bacteria responsible for infection and good bacteria of the intestinal flora. They are the perfect example of a double-edged medical sword8.

The resulting intestinal bacterial imbalance can lead to antibiotic-associated diarrhea (AAD)


Restaurer la flore intestinale avec l’aide des probiotiques

Several studies have confirmed the efficacy of the probiotic yeast Saccharomyces boulardii, also known as S. boulardii, in the preventive treatment of this unfortunate consequence of antibiotic therapy. This probiotic can not be affected by antibiotics and helps restore the intestinal flora to avoid unpleasant intestinal disturbances9.

infographie bacterie

Probaclac probiotics taken as supplementation while an antibiotic therapy are effective in combating antibiotic-associated diarrhea.

Probaclac Vaginal
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86%
reduction rate of Antibiotic associated diarrhea cases

A randomized, double-blind study of 151 hospitalized adult patients demonstrated the efficacy of the probiotic.

The placebo group developed diarrhea in a ratio of 9% while the supplemented group had a ratio of 1.4%, a 7.6% decrease10.

The beneficial effect of the probiotic was also replicated in a double-blind randomized controlled trial in 269 children aged 6 months to 14 years11.

The Probaclac Medic formula contains 5 billion active cells per capsule, the same amount as that administered to the experimental group in the study in the adult population.

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Bacterial Vaginosis

The vaginal flora is composed of microorganisms, including a very large quantity of lactobacilli bacteria, called the Döderlein flora, which represents approximately 95% of the vaginal ecosystem12.

Doderlein's good bacteria form a protective biofilm of the vaginal mucosa13.

The protective effect of lactobacilli is declined in different mechanism of action. Among other things, they inhibit the growth of pathogenic bacteria by secreting a variety of substances and impair their adhesion to vaginal epithelial cells by filling the surface14.


Although the Döderlein flora is a suitable protection, it is not foolproof and it is possible that an imbalance of the vaginal microbiota occurs.

The balance can be disturbed with a decrease in good bacteria, a proliferation of bad bacteria or yeasts13.


Various causes can lead to this imbalance :

  • including periods of hormonal variations such as pregnancy
  • external factors such as antibiotic therapy
  • excessive vaginal hygiene
  • sexual intercourse
  • stress
  • tobacco15.

Bacterial vaginosis is a disequilibrium that can be caused by the proliferation of a number of bacteria, including Gardnerella vaginalis or Prevotella, which are normally found in the sub-dominant vaginal flora14.

This change in the ecosystem involves an increase of the normally acidic vaginal pH and thus an infection. This infection is asymptomatic in half of women, however, when symptoms occur they are particularly bothersome for the affected woman16. Typically, they are characterized by heavy vaginal discharge of a gray/greenish smelly substance17.


Vaginose Bacterienne

The formula contains 8 billion bacteria of 3 different strains and helps to regulate the Döderlein flora by repopulating it.

Probaclac Vaginal
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84%
reduction rate of Bacterial Vaginosis cases

The effectiveness of Probaclac vaginal probiotics in reducing the recurrence of bacterial vaginosis has been scientifically proven

The formula contains 8 billion bacteria of 3 different strains and helps to regulate the Döderlein flora by repopulating it.

A study was conducted among 120 women with a history of recurrent bacterial vaginosis.

The results are conclusive and demonstrate that the insertion of probiotics into the vaginal cavity reduces the recurrence of bacterial vaginosis by more than 80%18.

CLINICALLY PROVEN EFFICACY

Vaginose Bacterienne tableau 1

Significant reduction of bacterial vaginosis rate over 2 months

Vaginose Bacterienne tableau 2

Significant reduction of bacterial vaginosis rate by G. Vaginalis over 2 months

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Resistance to stomach acid

Probaclac probiotic strains survive without an enteric-coated capsule in a pH of 3

Once consumed probiotics follow the natural path through the digestive tract. Starting in the mouth then traveling through the esophagus probiotics then reach the stomach, a very acidic environment when it is empty. Its acidity level varies according to what it contains, in the fasting stomach the pH is at around 1 and it rises to 6 when it is full.

The alkalization of the stomach when it contains nutrients is the reason why it is better to consume probiotics while eating. The number of active bacteria in the supplements can be affected if it faces a very acidic environment.

In order to ensure product efficacy, probiotic manufacturers must be able to demonstrate that their probiotic strains can withstand a pH3 environment. All strains of Probaclac supplements are able to survive an acid trip and therefore the viability of the bacteria is ensured to the intestines. An enteric-coated capsule is not needed for the bacteria to arrive safely. Not to mention that Lactobacillus strains are normally found in the stomach, the path traveled presents an opportunity to repopulate this flora.

Schema resistance gastrique

Références

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