THE DIFFERENT STUDIES ON PROBIOTICS
PREVENT C. DIFFICILE INFECTIONS
C. difficult
Clostridium difficile is a bacterium that normally resides without causing any problems in the intestine of approximately 5% of the population1. Following antibiotic treatment, bacterial colonization in the intestine decreases, which promotes the proliferation of C. difficile and therefore infection by the bacteria. Once well established, the bacteria produce toxins that can damage the intestine and cause diarrhea2. Clostridium difficile-associated diarrhea (CDAD) is the leading cause of nosocomial infectious diarrhea3.
Common Symptoms of C. Difficile Infection
Diarrhea
Abdominal cramps
Fever
Usually, people with the disease recover with antibiotic treatment, although research estimates that initial treatment fails in more than 20% of patients affected by this bacteria. 4 In fact, some more vulnerable patients may have severe complications such as severe inflammation of the intestine or advanced dehydration(2).
It is also possible to find blood, mucus or pus in the stool.
People taking antibiotics are 7 to 10 times more likely to suffer from the infection5. People in a hospital setting or in a nursing home are also at risk6.
Administration of Probaclac probiotics as a preventive measure to prevent the spread of C. difficile infections has been shown to be effective.
The Santa Cabrini Hospital in Montreal administered Probaclac Adult Formula probiotics to all patients receiving antibiotic treatment in an effort to control the spread of the infection.
Conducted over a period of 8 months and involving 5,000 individuals, the study was double-blind and carried out entirely independently of Laboratoires Nicar (9).
Following the probiotic therapy, CDAD cases decreased among the hospital’s patients.
Administering Probaclac probiotics as a preventive measure to stop the spread of C. difficile infections proved to be effective.
What is C. difficile?
Clostridium difficile is a bacterium that normally lives in the intestines of about 5% of the population without causing any issues. However, after antibiotic treatment, the balance of intestinal bacteria may be disrupted, allowing C. difficile to grow and potentially cause an infection. Once established, the bacteria produce toxins that can damage the intestines and lead to diarrhea.
Clostridium difficile-associated diarrhea (CDAD) is the leading cause of hospital-acquired infectious diarrhea.
Common symptoms of a C. difficile infection:
-
Diarrhea
-
Abdominal cramps
-
Fever
Most people affected recover with antibiotic treatment, although research estimates that initial treatment fails in over 20% of patients infected by this bacterium. Some more vulnerable individuals may experience serious complications, such as significant inflammation of the intestines or severe dehydration.
Blood, mucus, or pus may also be present in the stool.
People undergoing antibiotic therapy are 7 to 10 times more likely to develop the infection. Individuals in hospital settings or long-term care facilities are also considered at-risk populations.
C. difficult
Clostridium difficile is a bacterium that normally resides without causing any problems in the intestine of about 5% of the population. Following antibiotic treatment, bacterial colonization in the intestine decreases, which promotes the proliferation of C. difficile and therefore infection by the bacteria. Once well established, the bacteria produce toxins that can damage the intestine and cause diarrhea. Clostridium difficile-associated diarrhea (CDAD) is the leading cause of nosocomial infectious diarrhea.
Common Symptoms of C. Difficile Infection
Diarrhea
Abdominal cramps
Fever
Usually, people with the disease recover with antibiotic treatment, although research estimates that initial treatment fails in more than 20% of patients affected by this bacteria. In fact, some more vulnerable patients may have severe complications such as severe inflammation of the intestine or advanced dehydration.
It is also possible to find blood, mucus or pus in the stool.
People taking antibiotics are 7 to 10 times more likely to suffer from the infection. People in a hospital setting or in a nursing home are also at risk.
ANTIBIOTIC-ASSOCIATED DIARRHEA – AAD
Broad-spectrum antibiotics act against a wide range of bacteria to fight infections.
They are a powerful weapon that must be used with caution, as they target bacteria without distinguishing between the harmful pathogens causing the infection and the beneficial bacteria residing in the gut microbiota. They are the perfect example of a medical double-edged sword.
The resulting disruption of the intestinal bacterial balance can lead to antibiotic-associated diarrhea (AAD).
Antibiotic-associated diarrhea - AAD
Broad-spectrum antibiotics work against a wide range of bacteria to fight infections.
They are an effective weapon that must be handled with care since they attack bacteria without distinguishing between the pathogenic bacteria responsible for the infection and the good bacteria residing in the intestinal flora. They are the perfect example of a double-edged medical knife.
The intestinal bacterial imbalance thus caused can lead to antibiotic-associated diarrhea (AAD).
Restore intestinal flora with the help of probiotics
Probaclac probiotics taken in addition to antibiotic therapy are effective in combating antibiotic-associated diarrhea.
Several studies have confirmed the effectiveness of the probiotic yeast Saccharomyces boulardii, also known as S. boulardii, in the preventive treatment of this unfortunate consequence of antibiotic therapy.
This probiotic cannot be affected by antibiotics and helps restore the intestinal flora to avoid unpleasant intestinal disturbances.
A double-blind, randomized, controlled study in 151 hospitalized adult patients demonstrated the efficacy of the probiotic.
The placebo group developed diarrhea at a rate of 9% while the supplemented group had a ratio of 1.4%, a decrease of 7.6%.
The beneficial effect of the probiotic was also reproduced in a double-blind, randomized controlled trial in 269 children aged between 6 months and 14 years.
The Probaclac Medic formula contains 5 billion active cells per capsule, the same amount as that administered to the experimental group in the study on the adult population.
PROBACLAC MEDIC AND THE BENEFITS OF SACCHAROMYCES BOULARDII YEAST
Studies regarding Probaclac Medic
Several studies have confirmed the effectiveness of the probiotic yeast Saccharomyces boulardii, also known as S. boulardii, in the preventive treatment of this unfortunate consequence of antibiotic therapy.
This probiotic is not affected by antibiotics and helps restore the gut microbiota to prevent unpleasant intestinal disturbances.
A randomized, double-blind, controlled study involving 151 hospitalized adult patients demonstrated the probiotic’s effectiveness.
The placebo group developed diarrhea at a rate of 9%, while the supplemented group had a rate of only 1.4% — a 7.6% decrease.
The beneficial effect of the probiotic was also reproduced in a randomized, double-blind, controlled trial involving 269 children aged between 6 months and 14 years.
Probaclac Medic contains 5 billion active cells per capsule, the same dosage administered to the experimental group in the adult population study.
PROBACLAC GI AND THE BENEFITS OF THE LACTOBACILLUS RHAMNOSUS STRAIN
Recommended to prevent antibiotic-associated diarrhea.
Lactobacillus rhamnosus GG significantly reduces the risk of developing diarrhea related to antibiotic use.
Infectious Diarrhea
Infectious diarrhea is a form of acute diarrhea. The WHO defines it as the passage of at least three loose or liquid stools per day for less than two weeks. The causes fall into three categories: viruses, bacteria, and parasites.
Studies suggest that disrupted gut balance can be restored through rehydration and probiotic supplementation.
Lactobacillus rhamnosus GG is a well-documented probiotic strain that has shown numerous benefits for digestive and immune health in several clinical studies.
Lactobacillus rhamnosus GG has been clinically shown to promote the growth of friendly bacteria essential for maintaining a healthy balance in the intestinal microbiota.
The GG strain naturally has the ability to survive gastric acidity and act as a barrier against the development of harmful intestinal pathogens.
Clinical data on GG have demonstrated, among other things, its ability to reduce both the incidence and duration of diarrhea episodes caused by viral or bacterial infections.
BACTERIAL VAGINOSIS
The Probaclac Vaginal probiotic formula containing 8 billion bacteria from 3 different strains helps regulate the Döderlein flora by repopulating it.
The effectiveness of Probaclac Vaginal probiotics in reducing the recurrence of bacterial vaginosis has been scientifically proven.
The formula containing 8 billion bacteria from 3 different strains helps regulate the Döderlein flora by repopulating it.
A study was conducted among 120 women with a history of recurrent bacterial vaginosis.
The results are conclusive and demonstrate that the insertion of probiotics into the vaginal cavity reduces the recurrence of bacterial vaginosis by more than 80%.
Bacterial vaginosis
The vaginal flora is composed of a set of microorganisms including a very large quantity of lactobacilli bacteria, called the Döderlein flora which represents approximately 95% of the vaginal ecosystem.
Doderlein's good bacteria form a protective biofilm on the vaginal mucosa.
The protective effect of lactobacilli is expressed in different actions. Among others, they inhibit the growth of pathogenic bacteria by secreting a variety of substances and they impair their adhesion to vaginal epithelial cells by filling the surface.
Although Döderlein's flora is suitable protection, it is not infallible and it is possible that an imbalance of the vaginal microbiota may occur.
The balance can be disrupted by a decrease in good bacteria, an overgrowth of bad bacteria or even yeast.
The different causes that can lead to an imbalance:
periods of hormonal variations (eg pregnancy)
external factors such as antibiotic therapy
excessive vaginal hygiene
sexual intercourse
stress
tobacco.
Bacterial vaginosis is an imbalance that can be caused by the overgrowth of a number of bacteria, including Gardnerella vaginalis or Prevotella, which are normally found in the vaginal subdominant flora.
This change in the ecosystem involves an increase in the normally acidic vaginal pH and thus an infection. This infection is asymptomatic in half of women, however when symptoms do occur they are particularly inconvenient for the affected woman. Typically, they are characterized by abundant vaginal discharge of a foul-smelling gray/greenish substance.
Studies
Studies on Probaclac travelers
Studies
Resistance to gastric acidity
Probaclac probiotic strains survive without enteric coating at a pH of 3.
Once consumed, probiotics follow the natural path of the digestive tract. By crossing the mouth and then the esophagus, the probiotics then go to the stomach, a very acidic environment when it is empty. Its acidity level varies depending on what it contains, so when fasting the stomach has a pH of around 1 and a pH of more or less 6 when it is full.
The alkalization of the stomach when it contains nutrients is the reason why it is best to consume probiotics through food. The number of active bacteria in the supplements can be affected if it faces an overly acidic environment.
In order to guarantee the effectiveness of the products, probiotic manufacturers must be able to demonstrate that their probiotic strains can withstand a pH3 environment. All strains of Probaclac supplements are able to cope with this acidity and therefore the viability of the bacteria is ensured up to the intestines. No need for an enteric coating for the bacteria to arrive safely. Not to mention that Lactobacillus strains are found in the stomach naturally, the journey therefore presents an opportunity to repopulate this flora.
